·糖尿病与肥胖、脂质代谢异常·

2型糖尿病患者正常血清丙氨酸氨基转移酶水平与代谢综合征相关性的研究

　　范能光 张文 夏振华 金春花 张丽娟

　　【摘要】 目的 探讨T2DM患者正常范围内血清丙氨酸氨基转移酶(ALT)水平与代谢综合征(MS)的相关性。方法 选取319例ALT水平正常的T2DM患者按ALT四分位数分为4组(Q1～4组)，分析ALT水平与MS组间差异及其组分的关系。结果 随ALT水平升高，T2DM患者BMI、甘油三酯(TG)、尿酸(UA)和胰岛素抵抗指数(HOMA-IR)均逐渐升高(组间趋势P

　　【关键词】 糖尿病，2型;谷丙转氨酶;代谢综合征

Association between serum alanine aminotransferase in normal ranges and metabolic syndrome in T2DM patients FAN Neng-guang, ZHANG Wen, XIA Zhenghua, et al. Department of Endocrinology and Metabolism, the First Affiliated People’s Hospital, Shanghai Jiaotong University, Shanghai 201600, China

　　【Abstract】Objective To investigate the association between serum alanine aminotransferase (ALT) in normal ranges and metabolic syndrome (MS) in T2DM patients. Methods A total of 319 T2DM subjects with normal ALT levels were recruited to undergo anthropometric measurements and fasting blood sampling for biochemical assay such as blood glucose, lipid, uric acid and insulin. The subjects were divided into four (Q1～4) groups according to the quartiles of ALT, comparing the differences of metabolic indexes among them and analyzing the association between ALT levels and metabolic syndrome. Results BMI, triglyceride, uric acid, and insulin resistance index (HOMA-IR) were significantly elevated with the increase of ALT concentration (P for trend <0.05). Moreover, triglyceride and HOMA-IR were independent factors of ALT levels. The prevalence of MS, obesity, and hypertriglyceridemia was getting higher with the increase of ALT levels (P for trend <0.001). In Q1～4 groups, the prevalence of MS was 41.5%, 47.2%, 54.9%, and 65.9% respectively. ALT levels were also correlated with the risks of MS and most of its components. Compared with the Q1 group, the risks of MS, obesity, hypertension, and hypertriglyceridemia in the Q4 group were increased by 232%, 138%, 175%, and 256% respectively. Conclusion Serum ALT level in normal ranges is significantly associated with MS and its opponents in T2DM.

　　【Keywords】 Diabetes mellitus, type 2; Alanine aminotransferase (ALT); Metabolic syndrome (MS)