【摘要】目的 观察不同运动水平对新诊断肥胖T2DM患者代谢指标、胰岛功能及IS的影响。 方法 将74例新诊断肥胖T2DM患者随机分为强化运动组(强化组)及一般运动组(对照组)，两组均予糖尿病知识健康教育、饮食管理，予小剂量二甲双胍(0.5 g/ d);强化组运动200～250 min/周，对照组运动100～150min/周。干预8周及16周后对两组血脂、血压、BMI、FBG、FIns、FC-P、HBA1c、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)及胰岛素初期相分泌指数(△I30/△G30)进行比较。 结果 干预8周后强化组TG、TC、HBA1c、HOMA-IR明显低于对照组(P<0.05或P<0.01);16周后强化组在0 min、60 min血糖、TG、DBP、BMI、HBA1c，以及HOMA-IR明显低于对照组(P<0.05或P<0.01);HDL-C、FC-P及HOMA-β明显高于对照组(P<0.05或P<0.01)。 结论 新诊断肥胖T2DM患者通过增加运动量有益于代谢指标及胰岛功能的进一步改善。

　　【关键词】 糖尿病，2型;运动治疗;代谢指标;β细胞功能

　　Effect of increasing exercise intensity on newly diagnosed obese T2DM patients KONG Xian-ru, CAI Yan, XIE Fei. Department of Critical Care Medicine, Zhenjiang People’s Hospital Affiliated to Jiangsu University, Zhenjiang 212002, China

　　【Abstract】 Objective To investigate the effects of different exercise intensities on metabolism, β-cell function, and insulin sensitivity (IS) in newly diagnosed obese T2DM patients. Methods Seventy-four newly diagnosed obese T2DM patients were randomized into two groups, treated with exercise for 200~250 minutes per week (intensive group) and for 100~150 minutes per week (control group) respectively. Both groups were given diabetes propaganda, diabetic diet management, and small dose of metformin (0.5g/d). The results of blood lipid, blood pressure, BMI, FBG, FIns, FC-P, HBA1c, HOMA-IR, HOMA-β, and △I30/△G30 were determined and compared after 8 and 16 weeks’ treatment. Results Compared with the control group, the level of TG, TC, HBA1c, and HOMA-IR were decreased significantly in the intensive physical activity group (P<0.05 or P<0.01 ) after 8 weeks. After 16 weeks, the OGTT test was performed and the glucose level at 0 min and 60 min in the intensive physical activity group were significantly lower than in the control group (P<0.05 or P<0.01); the level of TG, DBP, BMI, HBA1c, and HOMA-IR were significantly lower (P<0.05 or P<0.01), however, the level of HDL-C, FC-P, and HOMA-β were increased significantly (P<0.05 or P<0.01) compared with the control group (P<0.05 or P<0.01).

　　Conclusions Increasing the intensity of physical activity will be beneficial to the improvement of metabolism indices and β-cell function in newly diagnosed T2DM patients.

　　【Key words】 Diabetes mellitus, type 2; Physical therapy; Metabolism indices; Islet β-cell function