【摘要】 目的 了解空腹血糖受损(IFG)与2型糖尿病(T2DM)患者血清瘦素和胰升血糖素水平的临床特点，初步研究瘦素和胰升血糖素与胰岛素抵抗(IR)的关系。方法 选取22例IFG者，22例新诊断的T2DM患者和48例正常对照(NC)，分别测定体质指数(BMI)、空腹血糖(FPG)、甘油三酯(TG)、空腹胰岛素(FIns)、瘦素、胰升血糖素，按公式计算胰岛素抵抗指数(HOMA-IR=FIns(mU/L)×FPG(mmol/L)/22.5)。结果 IFG与T2DM患者与 NC组相比，瘦素、胰升血糖素水平明显增高(P<0.05)，分别是5.86±1.71，5.73±1.68，4.83±1.82(ng/ml)，246.54±32.75, 278.37±42.56, 208.76±38.65(pg/ml);多因素分析，IFG与T2DM患者的瘦素水平与BMI、HOMA-IR呈正相关(r=0.58, 0.61, P<0.05); IFG与T2DM患者的胰升血糖素水平与HOMA-IR呈正相关(r=0.54, P<0.05)。 结论 (1) IFG与T2DM患者的瘦素和胰升血糖素比NC组升高。(2) T2DM患者的瘦素水平与BMI、HOMA-IR呈正相关; IFG与T2DM患者的胰升血糖素水平与HOMA-IR呈正相关

　　【关键词】糖尿病，2型; 瘦素; 胰升血糖素; 胰岛素抵抗

　　Clinical study on the levels of leptin and glucagon in impaired fasting glucose and newly diagnosed type 2 diabetic patients WANG Ya-lin, ZOU Rong, YU Rui-ping, et al. Department of Endocrinology, Guizhou Provincial People’s Hospital, Guiyang 550002, China

　　Corresponding author: WANG Ya-lin, E-mail: yalinwang79@yahoo.com.cn

　　【Abstract】 Objective To investigate the clinical characteristics of serum levels of leptin and glucagon in impaired fasting glucose (IFG) and newly diagnosed T2DM patients and study the relationship of leptin and glucagon with insulin resistance (IR). Methods Twenty-two impaired fasting glucose patients, 22 newly diagnosed T2DM patients, and 48 matched normal controls were enrolled in the study. Their BMI, fasting plasma glucose (FPG), triglyceride (TG), fasting insulin (FIns), leptin, and glucagon were measured. The HOMA-IR was calculated with the formula: HOMA-IR = FIns(mU/L)×FPG(mmol/L)/22.5. Results Compared with the normal controls, the IFG and T2DM patients had higher levels of leptin and glucagon (P<0.05), as 5.86±1.71，5.73±1.68，4.83±1.82(ng/ml)，246.54±32.75, 278.37±42.56, 208.76±38.65(pg/ml), respectively. Multifactorial analysis showed that in IFG and T2DM patients there was a positive correlation of the level of leptin with BMI and HOMA-IR (r=0.58, 0.61, P<0.05), while there was a positive correlation between the level of glucagon and HOMA-IR (r=0.54, P<0.05). Conclusions 1). The serum levels of leptin and glucagon in IFG and newly diagnosed T2DM patients are higher than those in the control group. 2). There is a positive correlation of the level of leptin in IFG and T2DM patients with BMI and HOMA-IR; there is a positive correlation between the level of glucagon in IFG and T2DM patients and HOMA-IR.

　　【Key words】 Diabetes mellitus, type 2; Leptin; Glucagon; Insulin resistance (IR)