·文献综述·

　　侯文芳 王海宁 洪天配

　　作者单位：100191北京大学第三医院内分泌科

　　通讯作者：洪天配，E-mail: tpho66@bjmu.edu.cn

　　【提要】近年研究表明，慢性炎症在胰岛素抵抗(IR)的发生和发展中具有重要意义。白介素18(IL-18)作为一种重要的炎症介质与IR有着密切的关系。本文主要综述了IL-18对IR的影响及可能机制。

　　【关键词】白介素18;胰岛素抵抗

　　doi:10.3969/j.issn.1006-6187.2012.02.021

　　Interleukin-18 and insulin resistanceHOU Wen-fang, WANG Hai-ning, HONG Tian-pei.Department of Endocrinology, Peking University Third Hospital， Beijing 100191, China

　　Corresponding author: HONG Tian-pei, E-mail: tph066@bjmu.edu.cn

　　【Summary】Recent studies showed that chronic inflammations played important roles in the pathogenesis of insulin resistance(IR). Interleukin 18(IL-18), as an important inflammatory cytokine, might be closely related to insulin resistance. In this article, we reviewed the effects and mechanisms of IL-18 on insulin resistance .

　　【Key words】Interleukin-18;Insulin resistance