来自:中国糖尿病资讯网 编辑:editor|点击数:|2012-03-06
·糖尿病临床研究·
温娟娟 陈莉明 单春艳 郑妙艳 杨菊红 王颖 任慧珠 孙红喜 郭俊 常宝成
作者单位:300070天津,天津医科大学代谢病医院糖尿病肾病科, 卫生部及天津市激素与发育重点实验室
通讯作者:常宝成,E-mail:changbc1970@126.com
【摘要】目的观察口服降糖药控制不佳的T2DM患者HbA1c与β细胞功能的关系。方法T2DM患者464例,按HbA1c水平分为4组:A组,HbA1c≤7.0%;B组,7.0%11.0%。比较各组间HOMA-IR、HOMA-β、早时相胰岛素分泌指数(△I30/△G30)、晚时相胰岛素分泌等的变化。结果随HbA1c升高,HOMA-β、△I30/△G30、胰岛素曲线下面积(AUCI)均逐渐降低(P<0.01),以△I30/△G30最明显(各组△I30/△G30自然对数值依次为1.00±0.15、0.50±0.07、0.40±0.05、0.10±0.03);随HbA1c升高,HOMA-IR呈升高趋势,B、C、D组(分别为1.1±0.4、1.2±0.3、1.2±0.4)明显高于A组(0.8±0.3)(P<0.01)。结论口服降糖药控制不佳的T2DM患者,随HbA1c的升高,在胰岛素抵抗增加的同时,β细胞分泌功能也受到抑制,尤以早时相胰岛素分泌为著。
【关键词】糖尿病,2型;HbA1c;早时相胰岛素分泌;胰岛素抵抗
doi:10.3969/j.issn.1006-6187.2012.02.013
The correlation between glycated hemoglobin A1c and islet β cell function in poorly controlled type 2 diabetic patients treated with oral antidiabetic drugs WEN Juan-juan, CHEN Li-ming ,SHAN Chun-yan, et al. Department of Nephrology,Metabolic Diseases Hospital,Tianjin Medical University,Key Lab of Hormones and Development,Ministry of Health and Tianjin,Tianjin 300070,China
Corresponding author: CHANG Bao-cheng, E-mail: changbc1970@ 126. com
【Abstract】ObjectiveTo investigate the correlation between islet β cell function and glycated hemoglobin A1c(HbA1c) in poorly controlled type 2 diabetic patients treated with oral antidiabetic drugs. Methods464 cases of type 2 diabetic patients were divided into four groups: HbA1c≤7.0% (Group A),7.0%11.0%(Group D). ResultsThe gradually increased levels of HOMA-IR and AUCg were found and gradually decreased levels of HOMA-β, ISI, △I30/G30, and DI occurred along with the increase of HbA1c. ConclusionsIn poorly controlled type 2 diabetic patients treated with oral antidiabetic drugs, insulin resistance is elevated while islet β cell function,especially the early phase insulin secretion, is decreased, along with the increase of HbA1c.
【Key words】Diabetes mellitus,type 2; HbA1c; Early phase insulin secretion; Insulin resistance
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