·糖尿病的胰岛素治疗·

　　李敬华 刘丽楠 王素莉 庞娟 霍嫔凤 赵彩玲 刘晓宇 关树梅

　　作者单位：300162天津，武警医学院附属医院内分泌科

　　【摘要】目的评价甘精胰岛素治疗新诊断T2DM患者的降糖效果及对胰腺功能的影响。方法新诊断T2DM患者50例，随机分为治疗组(甘精胰岛素联合二甲双胍、阿卡波糖)和对照组(格列美脲联合二甲双胍、阿卡波糖)，治疗12周。结果治疗后两组HbA1c、FBG、2hBG较治疗前显著下降(P<0.01);治疗组FC-P及2hC-P显著高于对照组(P<0.05)，低血糖发生次数显著低于对照组(P<0.05)。结论甘精胰岛素联合口服药物能够有效降低血糖、促进胰岛β细胞功能恢复、低血糖发生少，为新诊断T2DM患者行之有效的降糖方案。

　　【关键词】糖尿病，2型;甘精胰岛素;格列美脲

　　doi:10.3969/j.issn.1006-6187.2012.02.011

　　Treatment evaluation of insulin glargine in newly diagnosed type 2 diabetes mellitusLI Jing-Hua，LIU Li-Nan，WANG Su-Li，et al.Department of Endocrinology，Affiliated Hospital of the Medical College of Chinese people′s Armed Police Forces，Tianjin，China，300162

　　【Abstract】ObjectiveTo evaluate the treatment of insulin glargine in newly diagnosed type 2 diabetes mellitus and the effect on pancreatic islet β cells. MethodsFifty patients with newly diagnosed type 2 diabetes were randomly divided into treatment group (n=25,insulin glargine combined with metformin and acarbose) and control group (n=25,glimepiride combined with metformin and acarbose), and all the patients were treated for 12 weeks. ResultsThere were no significant differences between two groups in HbA1c, FBG, 2hBG, FC-P and 2hC-P before the test.HbA1c, FBG, 2hBG of the two groups decreased after the treatment(P<0.01); FC-P and 2hC-P in the treatment subjects were higher than those in the control subjects (P<0.05); Compared with the control group, the frequency of hypoglycemia in the treatment group was lower during the test (P<0.05). ConclusionCombined treatment of insulin glargine with metformin and acarbose for newly diagnosed type 2 diabetes mellitus, can effectively reduce fasting and postprandial blood glucose with fewer hypoglycemia, and also recover the function of islet β cells. So,it will provide an effective therapy for newly diagnosed type 2 diabetes mellitus.

　　【Key words】Diabetes mellitus，Type 2;Insulin glargine;Glimepiride