·糖尿病视网膜病变·

　　蔡芸莹 马中书 邱明才

　　作者单位：300052天津医科大学总医院内分泌科

　　【摘要】目的比较T2DM视网膜病变(DR)不同时期，尿蛋白、肾小球滤过率(GFR)变化，寻找早期筛查DR的指标。方法采用回顾性病历研究，根据散瞳眼底检查分组，同期测定各组24h尿白蛋白定量，以MDRD公式计算GFR。结果与正常眼底组相比，DR组患者的GFR明显减低(P<0.05)，且尿白蛋白(UAlb)、GFR均与DR呈显著独立相关(P<0.05)。结论UAlb、GFR均与DR密切相关，其联合筛查有利于DR早期检出。

　　【关键词】糖尿病视网膜病变;肾小球滤过率;尿白蛋白

　　doi:10.3969/j.issn.1006-6187.2012.02.008

　　The correlation of albuminuria and glomerular filtration rate with diabetic retinopathy in type 2 diabetesCAI Yun-ying,MA Zhong-shu,QIU Ming-cai. Department of Endocrinology, Tian jin Medical University General Hospital, Tianjin 300052

　　【Abstract】ObjectiveTo compare changes of urinary albumin and eGFR between different stages of diabetic retinopathy(DR) to look for early screening diabetic retinopathy indicators.MethodsThe clinical data were analyzed retrospectively.Diabetic retinopathy was assessed by mydriatic ophthalmoscopy.While determinating the urinary albumin quantitative for 24 hours, the estimated glomerular filtration rate(GFR) was measured by MDRD formula.ResultsThe levels of GFR were significantly lower in two DR groups than in normal retina group(P<0.05). Both urinary albumin(UAlb) and GFR were independently risks for diabetic retinopathy.ConclusionUAlb and GFR are closely associated with diabetic retinopathy.Clinicians need to check both urinary albumin and eGFR to screen for early diabetic retinopathy.

　　【Key words】Diabetic retinopathy; Glomerular filtration rate; Urinary albumin