【摘要】 目的 了解正常妊娠早期妇女HbA1c的水平，为妊娠糖尿病(GDM)的早期诊断提供理论基础。 方法 纳入468例8～14周时正常孕妇，另纳入125例正常非孕育龄妇女，两组均测定年龄、BMI、血红蛋白(Hb)、平均红细胞体积(MCV)、FPG及HbA1c进行组间比较。 结果 非孕妇女HbA1c水平为(5.45±0.31)%，正常妊娠早期妇女HbA1c水平为(5.12±0.25)%，两组间差异有统计学意义(P<0.05)。正常妊娠早期妇女HbA1c水平与年龄、FPG呈正相关，(r=0.15，0.25)，与MCV呈负相关(r=-0.21)，与Hb及BMI无相关性(P>0.05)。 结论 正常妊娠早期妇女HbA1c的水平低于正常非孕妇女，提示其控制上线为5.6%，当大于此值时可能需早期进行干预或按GDM管理治疗。

　　【关键词】 早期妊娠; 糖化血红蛋白; 妊娠糖尿病

　　Investigation of HbA1c level in early normal pregnant women LI Jian, FENG Li, LONG Wei-dong, et al. Department of Clinical Laboratory, The People’s Hospital of Banan District, Chongqing 401320,China

　　【Abstract】Objective To explore the HbA1c level in early normal pregnancy to provide theoretical basis for the diagnosis of gestational diabetes mellitus (GDM). Methods The 468 normal pregnant women were carded with determination of age, BMI, hemoglobin (Hb), mean red cell volume (MCV), FPG, and HbA1c. The data were statistically processed. In addition, the 125 healthy non-pregnant women with the same determinations were attributed into the control group for comparison. Results The level of HbA1c in healthy non-pregnant women was 5.45±0.31%, while that of early pregnant women was 5.12±0.25%, and the difference was statistically significant (P<0.05). The level of HbA1c in early pregnant women was positively correlated to age and FPG (r=0.15，0.25), negatively correlated to MCV (r=-0.21), and not correlated to Hb and BMI (P>0.05). Conclusion The HbA1c level in early normal pregnant women is lower than that in healthy non-pregnant women, suggesting that control line is 5.6%, and 5.6% plus meaning that prompt interference or GDM management needs to be taken.

　　【Key words】 Early pregnancy; Hemoglobin A1c (HbA1c); Gestational diabetes mellitus (GDM)