【摘要】 目的 探讨磺脲类(SUs)降糖药对糖尿病合并急性心肌梗死(AMI)患者住院病死率的影响。 方法： 回顾性收集AMI患者(365例伴糖尿病，1803例无糖尿病)住院期间临床资料，分析糖尿病患者AMI发生时使用SUs是否对其预后具有独立影响。结果：糖尿病患者AMI的住院病死率明显高于同期非糖尿病AMI患者(22.2% vs.13.2%，P<0.01)。在糖尿病合并AMI患者中，使用SUs药物的患者住院期间病死率低于非SUs药物治疗者(13.8% vs.32.4%)。多因素回归分析显示，AMI发生时使用SUs是糖尿病合并AMI患者的保护因素。 结论： AMI住院期间使用磺脲类药物不会增加糖尿病患者AMI的住院病死率。

　　【关键词】 磺脲类(SUs)降糖药;住院病死率;心肌梗死

　　Effect of previous treatment with Sulfonylureas on survival in patients with diabetes mellitus after myocardial infarction. LI Chun, YU Ye-rong. Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China

　　Corresponding author: YU Ye-rong

　　【Abstract】 Objective To assess the in-hospital outcome of diabetic patients with acute myocardial infarction (AMI) according to the use of Sulfonylureas (SUs) at the time of the acute episode. Methods In this retrospective study, the in-hospital clinical data of AMI cases (365 with diabetes and 1803 without diabetes) were collected to analyze whether the use of SUs influenced their prognosis on survival. Results In-hospital mortality of the diabetics complicated with AMI was significantly higher than that of those non-diabetics (22.2% vs 13.2%, P<0.01). Among the diabetics complicated with AMI, the in-hospital mortality of those taking SUs was lower than that of those without taking SUs (13.8% vs 32.4%). The multivariate Logistic regression analysis showed that the use of SUs in the AMI episode was a protective factor for the diabetics. Conclusion The use of SUs in AMI diabetics was not associated with the increased in-hospital mortality.

　　【Key words】 Sulfonylureas (SUs); In-hospital mortality; Myocardial infarction