·糖尿病的胰岛素治疗·

闫晓光 张锦 仲维莉 魏倩 王震静 丁丽 王雪鹰

基金项目：辽宁省医学科技创新工程项目[辽卫函字〔2004〕378号]

作者单位：110001沈阳，中国医科大学附属第一医院内分泌科(第一作者现在齐齐哈尔市第一医院内分泌二科工作)

通讯作者：张锦，E-mail:zhangjininsy@gmail.com

【摘要】 目的 评价甘精胰岛素和预混胰岛素在老年T2DM治疗中的优越性。 方法 68例老年T2DM患者随机分为甘精胰岛素组(Gla组)和预混胰岛素组(Pre组)，比较两组治疗前后FBG、2hBG、HbA1c、空腹C肽(FC-P)及75g OGTT后2hC肽(2hC-P)水平、体重变化、低血糖发生率及患者满意度。 结果 治疗后两组FBG、2hBG、HbA1c水平均较治疗前显著降低(P<0.01)，Gla组FBG、HbA1c水平较Pre组显著降低(P<0.05)，Pre组2hC-P水平较治疗前显著增加(P<0.05)。Gla组体重增加、低血糖发生率显著低于Pre组(P<0.05或P<0.01)。 结论 老年T2DM患者应用甘精胰岛素是有益的治疗方案。

【关键词】 老年糖尿病患者;甘精胰岛素;预混胰岛素

全文请见《中国糖尿病杂志》2011年7月 第19卷 第7期

doi:10.3969/j.issn.1006-6187.2011.07.009

The comparison of therapeutic effects and adverse reactions between insulin glargine and premixed insulin therapy for aged type 2 diabetic patients

YAN Xiao-guang, ZHANG Jin, ZHONG Wei-li, et al. Department of Endocrinolog,the First Affiliated Hospital, China Medical University, Shenyang 110001,China

Corresponding author:ZHANG Jin, E-mail: zhangjininsy@gmail.com

【Abstract】 Objective To compare the efficacy and safety between insulin glargine and premixed insulin therapy in aged type 2 diabetic patients. Methods 68 aged type 2 diabetic patients were randomized to two groups of insulin glargine and premixed insulin (Novolin 30R) therapy. Insulin dosage was titrated to serum glucose target. All patients were observed for 6 months. Results Mean FBG, 2h BG and HbA1c were significantly(P<0.01) decreased from baseline in both groups. Insulin glargine yielded better FBG and HbA1c values than did premixed insulin(P<0.05). Serum 2h CP concentration was increased in premixed insulin group and was higher than in glargine group(P<0.05). Patients in group of insulin glargine suffered from fewer hypoglecemia and gained less weight(P<0.05，P<0.01). Conclusion Insulin glargine is safer and more effective for aged type 2 diabetic people.

【Key words】 Aged diabetic patients; Insulin glargine; Premixed insulin