·糖尿病心血管病·

张元春 罗常有 尹庆 吴家宽 孙金玲

基金项目：东莞市科学技术局资助项目(2007105150053)

作者单位：523110东莞，中山大学附属东华医院心血管内科

通讯作者：罗常有，E-mail: changyouluo@yahoo.com.cn

【摘要】 目的 探讨糖调节受损(IGR)的急性冠脉综合征(ACS)患者冠状动脉病变特点及侧支循环(CC)情况。 方法 确诊为ACS的166例患者按糖耐量试验(OGTT)分成糖尿病(DM)组56例、糖调节受损(IGR)组66例及血糖正常(NGT)组44名。 结果 IGR组及DM组较NGT组更容易发生多支血管病变(P<0.05)和严重狭窄病变(P<0.05)，但侧支循环建立无明显差别( P>0.05)。 结论 早在IGR期冠状动脉就可以有动脉粥样硬化病变，需要尽早加以防治。

【关键词】 糖调节受损;糖尿病;急性冠脉综合征;侧支循环

doi:10.3969/j.issn.1006-6187.2011.07.006

Impact of impaired glucose regulation on Gensini score in acute coronary syndrome (ACS) patients

ZHANG Yuan-chun, LUO Chang-you, YIN Qing, et al.

Department of Cardiology, The Affiliated Tungwah Hospital,Sun Yat-sen University, Dongguan 523110， China

Corresponding author: LUO Chang-you, E-mail:changyouluo@yahoo.com.cn

【Abstract】 Objective To approach the effect of impaired glucose regulation on Gensini score and coronary lesion severity in ACS patients. Method s166 consecutive patients with confirmed CAD (coronary artery disease) from August 2006 to Oct 2008 underwent oral glucose tolerance test (OGTT). 56 cases met the criteria for diabetes mellitus (DM), 66 for impaired glucose regulation (IGR) and another 46 patients for normal glucose tolerance (NGT). Result sCompared to normal glucose patients, patients with diabetes or impaired glucose regulation were more likely to develop multivessel disease (P<0.05) and severe stenosis lesions (P<0.05). However, coronary collaterals in patients with DM or IGR (P>0.05) were similar to normal glucose patient. Conclusion Coronary atherosclerosis may occur during the IGR stage, indicating IGR and DM are the same hazardous factor. Something should be done as soon as possible to prevent the damage by IGR.

【Key words】 Impaired glucose regulation; Diabetes mellitus; Acute coronary syndrome; Collateral circulation