·糖尿病周围神经病变·

　　张菁邓晓龙王敏哲

　　作者单位：830011乌鲁木齐，新疆医科大学第五附属医院内分泌科

　　通讯作者：王敏哲，E-mail：jenny197654@sohu.com

　　【摘要】 目的 评价α-硫辛酸联合甲钴胺及前列地尔治疗糖尿病周围神经病变(DPN)的疗效。 方法 将32例患者随机分为两组：治疗组予α-硫辛酸、甲钴胺及前列地尔，对照组予甲钴胺及前列地尔，治疗2周。观察两组临床疗效及神经传导速度(NCV)。 结果 治疗组总有效率达87.5%，明显高于对照组的50%(P<0.05);两组患者的神经病变主觉症状问卷(TSS)评分明显改善(P<0.05);治疗组NCV较对照组有显著提高(P<0.01)。 结论 临床使用α-硫辛酸联合甲钴胺及前列地尔治疗DPN安全有效。

　　【关键词】糖尿病神经病变;α-硫辛酸;甲钴胺;前列地尔

　　doi:10.3969/j.issn.1006-6187.2011.04.011

　　Therapeutic effect of α-lipoic acid combined with mecobalamin and alprostadil on diabetic peripheral neuropathy

　　ZHANG Jing，DENG Xiao-long，WANG Min-zhe. Department of Endocrinology, The Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China

　　Corresponding author：WANG Min-zhe, E-mail: jenny197654@sohu.com

　　【Abstract】 Objective To evaluate the therapeutic effect of α-lipoic acid combined with mecobalamin and alprostadil on diabetic peripheral neuropathy(DPN). Methods The 32 DPN patients receiving a 2 weeks of therapy were randomly divided into two groups: treatment group treated with α-lipoic acid combined with mecobalamin and alprostadil and control group treated with mecobalamin and alprostadil. The therapeutic effect and nerve conduction velocity(NCV)were observed. Results The total efficacious rate was higher in treatment group than in control group (87.5% vs 50.0%, P<0.05). TSS score improvement in treatment group was superior to control group (P<0.05). NCV acceleration was more in treatment group than in control (P<0.01). Conclusions Treatment with α-lipoic acid combined with mecobalamin and alprostadil in patients with DPN is safe and effective.

　　【Key words】Diabetic neuropathies; Lipoic acid; Mecobalamin;Alprostadil