·糖尿病周围神经病变·

　　白然 王亚军 杨郁 巴颖 邢倩 杜建玲 李昌臣

　　作者单位：116011大连，大连医科大学附属第一医院内分泌科

　　【摘要】 目的 探讨血浆同型半胱氨酸(Hcy)水平与糖尿病胃肠神经病变(DGN)的关系及2型糖尿病(T2DM)患者发生胃肠神经病变的危险因素。 方法 60例T2DM患者分为无DGN(NDGN)组31例和DGN组29例，30名健康体检者作为正常对照(NC)组，分别采血测定空腹Hcy等指标。 结果 NDGN组和DGN组的血浆Hcy水平均高于NC组(P<0.05)。DGN组Hcy水平略高于NDGN组，但差异无统计学意义(P>0.05)。年龄及病程与DGN显著相关(P<0.05)。 结论 血浆Hcy浓度升高可能与DGN的发生发展无关，年龄及病程是DGN的独立危险因素。

　　【关键词】同型半胱氨酸;糖尿病，2型;糖尿病胃肠神经病变

　　doi:10.3969/j.issn.1006-6187.2011.04.010

　　Relationship between plasma homocysteine level and type 2 diabetic gastrointestinal neuropathy

　　BAI Ran，WANG Ya-jun，YANG Yu，et al. Department of Endocrinology，The First Affiliated Hospital of Dalian Medical University，Dalian 116011，China

　　【Abstract】 Objective To investigate the relationship between the plasma homocysteine level(Hcy)and type 2 diabetic (T2DM) gastrointestinal neuropathy， and to find the risk factors for gastrointestinal neuropathy. Methods The study subjects included three groups： control groups(NC)，T2DM without gastrointestinal neuropathy (Non-DGN) and diabetic gastrointestinal neuropathy group (DGN). The fasting plasma Hcy concentration and electrogastrogram were determined. Results Plasma levels of Hcy were higher in total diabetes groups than in control group (P<0.05). The Hcy level was higher in DGN group than in non-DGN group，but there was no significant difference(P>0.05). The Spearman correlation analysis and logistic regression analysis showed that age and duration were independent risk factors for diabetic gastrointestinal neuropathy. Conclusions High Hcy levels may not be associated with diabetic gastrointestinal neuropathy. Age and duration may be the risk factors for the development of gastrointestinal neuropathy in type 2 diabetic patients.

　　【Key words】Homocysteine; Diabetes mellitus，type 2; Diabetic gastrointestinal neuropathy