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糖耐量正常的2型糖尿病一级亲属氧化应激水平与胰岛素敏感性的相关性研究

来自:中国糖尿病资讯网  编辑:admin|点击数:|2011-10-20

  基金项目:河北省卫生厅指令性计划(08024)

  李萍 宋光耀 卢亚敏 马博清 刘晶

  作者单位:050051 石家庄,河北省人民医院内分泌二科

  通讯作者:宋光耀,E-mail:sguangyao@sohu.com

  【摘要】目的 观察2型糖尿病(T2DM)患者及糖耐量正常的T2DM一级亲属(FDRs)体内氧化应激状态,探讨氧化应激与胰岛素敏感性之间的关系。 方法 检测外周血清丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)、 8-异前列腺素F2α(8-iso-PGF2α)水平,高胰岛素正葡萄糖钳夹技术评估胰岛素敏感性。 结果 T2DM组、FDRs组较NC组MDA、8-iso-PGF2α水平升高(P<0.05),而血GSH-PX、SOD水平降低,差异有统计学意义(P<0.05);MDA、8-iso-PGF2α与葡萄糖输注速率(GIR)呈明显负相关(r=-0.415和-0.443,P<0.05),GSH-PX、SOD与GIR呈明显正相关(r=0.327和0.439,P<0.05)。 结论 T2DM患者及糖耐量正常的T2DM一级亲属存在氧化应激状态的改变,且与胰岛素敏感性密切相关。

  【关键词】糖尿病,2型;一级亲属;氧化应激;胰岛素敏感性

  The relationship between oxidative stress and insulin sensitivity in the NGT first degree relatives of type 2 diabetes

  LI Ping, SONG Guang-yao, LU Ya-min, et al. Department of Endocrinology, Hebei Provintial Hospital, Shijiazhuang 050051, China

  Corresponding author:SONG Guang-yao, E-mail: sguangyao@sohu.com

  【Abstract】 Objective To study the relationship of serum oxidative stress with insulin sensitivity in type 2 diabetes mellitus (T2DM) and NGT first degree relatives (FDRs) of T2DM. MethodsFasting level of MDA,GSH-PX, SOD, 8-iso-PG-F2α, and FFA was measured in T2DM patients, NGT first degree relatives (FDRs) of T2DM and normal controls. Insulin sensitivity was evaluated by euglycemic hyperinsulinemia clamp technique. Results The level of MDA and 8-iso-PG-F2α was significantly higher in both T2DM and FDRs than that in control group (P<0.05), and the level of GSH-PX and SOD was lower in FDRs than in controls and higher in FDRs than in diabetics. Conclusions Oxidative stress may play an important role in the development of T2DM.

  【Key words】Diabetes mellitus, type 2;First degree relatives;Oxidative stress; Insulin sensitivity

上一篇:不同体质指数的2型糖尿病患者血管性血友病因子水平和胰岛素抵抗的临床研究 下一篇:尿白蛋白排泄率异常的2型糖尿病患者尿N-乙酰-β-葡萄糖苷酶、α1-微球蛋白及视黄醇结合蛋白检测的改变