来自:中国糖尿病杂志 编辑:朱常青 陈波 伍绍国 孙燕 李婉媚|点击数:|2016-04-05
【关键词】 糖尿病,2型;胰岛素强化治疗;胰岛β细胞功能
Clinical observation of the effect of islet function in extend the duration of insulin treatment after the continuous subcutaneous insulin infusion therapy ZHU Chang-qing, CHEN Bo, WU Shao-guo, et al. Department of Endocrinology, The Twelfth Affiliated People’s Hospital of Guangzhou Medical College, Guangzhou 510620, China
Corresponding author: CHEN Bo, E-mail:cblinxiang726@163.com
【Abstract】 Objective To investigate of the effect of islet β cell function in extend the duration of insulin treatment after the continuous subcutaneous insulin infusion therapy in newly diagnosed type 2 diabetic patients (T2DM). Methods 90 newly diagnosed T2DM were randomly divided into three groups with intensive insulin therapy for 2 weeks, 3 months and 5 months respectively. The islet β cell function was measured before and 1 year after treatment, and the differences were compared among each group. Results The plasma glucose was controlled well and the islet β cell function was significantly improved in each group after treatment. The ratio value of △I30/△G30 in group of 3 months, 5 months were higher than group of 2 weeks [(1.87±0.44) vs ( 1.95±0.49) vs (1.63±0.51),P﹤0.01]. At 1 year after treatment , HbA1c was significantly lower [(5.57±0.27)% vs ( 7.76±0.55)%,P﹤0.05], △I30/△G30 was higher [(1.39±0.78) vs (1.82±0.29),P﹤0.05] and the descending rate of isletβcell function was slower [(303.71±46.12) vs (200.69±29.42),P﹤0.05] in the remission group than the non-remission group (P﹤0.05). The ratio of remission in group of 3 months and 5 months was higher than 2 weeks [53.3% vs 63.3%vs 40.0%,P﹤0.05]. Conclusion Intensive insulin therapy can significantly improve the isletβ cell function of newly diagnosed T2DM. An appropriate extension for 3-5months of insulin treatment can further prevent the descending of isletβcell function.
【Key words】 Diabetic mellitus, type 2; Intensive insulin therapy; Islet β cell function
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