【关键词】  糖尿病,2型；胰岛素强化治疗；胰岛β细胞功能

Clinical observation of the effect of islet function in extend the duration of insulin treatment after the continuous subcutaneous insulin infusion therapy  ZHU Chang-qing, CHEN Bo, WU Shao-guo, et al. Department of Endocrinology, The Twelfth Affiliated People’s Hospital of Guangzhou Medical College, Guangzhou 510620, China

Corresponding author: CHEN Bo, E-mail:cblinxiang726@163.com

【Abstract】  Objective  To investigate of the effect of islet β cell function in extend the duration of insulin treatment after the continuous subcutaneous insulin infusion therapy in newly diagnosed type 2 diabetic patients (T2DM).  Methods  90 newly diagnosed T2DM were randomly divided into three groups with intensive insulin therapy for 2 weeks, 3 months and 5 months respectively. The islet β cell function was measured before and 1 year after treatment, and the differences were compared among each group. Results The plasma glucose was controlled well and the islet β cell function was significantly improved in each group after treatment. The ratio value of △I₃₀／△G₃₀  in group of 3 months, 5 months were higher than group of 2 weeks [(1.87±0.44) vs ( 1.95±0.49) vs (1.63±0.51),P﹤0.01]. At 1 year after treatment , HbA₁c was significantly lower [(5.57±0.27)% vs ( 7.76±0.55)%，P﹤0.05], △I₃₀／△G₃₀ was higher [(1.39±0.78) vs (1.82±0.29)，P﹤0.05] and the descending rate of isletβcell function was slower [(303.71±46.12) vs (200.69±29.42)，P﹤0.05] in the remission group than the non-remission group (P﹤0.05). The ratio of remission in group of 3 months and 5 months was  higher than 2 weeks [53.3％ vs  63.3％vs 40.0％，P﹤0.05]. Conclusion Intensive insulin therapy can significantly improve the isletβ cell function of newly diagnosed T2DM. An appropriate extension for 3-5months of insulin treatment can further prevent the descending of isletβcell function.

【Key words】  Diabetic mellitus, type 2;  Intensive insulin therapy;  Islet β cell function