【关键词】  糖尿病,2型; 焦虑状态; 糖化血红蛋白

Association of anxiety and hemoglobin A₁c in patients with type 2 diabetes mellitus  ZHANG Pan, LOU Pei-an, LOU He-qing, et al. Xuzhou Medical College， Xuzhou 221009，China

Corresponding author: LOU Pei-an, E-mail: lpa82835415@126.com

【Abstract】  Objective  To investigate the association between anxiety and hemoglobin A₁c (HbA₁c) in patients with type 2 diabetes mellitus (T2DM).  Methods  Cluster sampling was used in this study. The self-designed questionnaire, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) questionnaire were filled out by all participants. HbA₁c were measured in all subjects. Multiple stepwise regression analyse was used to examine the association between anxiety and HbA₁c.  Results  Target HbA₁c achievement rate were significantly different in T2DM patients with and without anxiety (17.89% vs 25.65% respectively, χ²=8.51, P=0.01). Target HbA₁c achievement rates in patient with ‘no anxiety’, ‘mild anxiety’, ‘moderate anxiety’ and ‘severe anxiety’ were 25.65%,18.96%,15.18% and 0.00% respectively. The more serious of anxiety, the lower glycemic control rate(χ²_trend =10.27,P＜0.01), and the higher average value of HbA_lc（F=4.24，P＜0.01）. Multiple stepwise regression analysis showed that gender, residential pattern, per capita monthly income, duration of diabetes and anxiety were risk factors for HbA1c.  Conclusion  Anxiety is associated with HbA₁c in T2DM patients.

【Key  words】  Diabetes mellitus, type 2; Anxiety; Hemoglobin A₁c