·糖尿病性肾脏疾病·

　　【摘要】 目的 观察糖尿病慢性肾脏疾病(CKD)患者血清唾液酸(SA)的变化，及其与血管内皮功能的关系。 方法 选取T2DM患者97例，根据UAlb/Cr水平分为<30 mg/24 h组31例、30～299 mg/24 h组34例、≥300 mg/24 h组32例，另选取健康体检者30名作为对照(NC)组，检测各组血清SA、一氧化氮(NO)、内皮素-1(ET-1)水平。 结果 与NC组比较，<30 mg/24 h、30～299 mg/24 h、≥300 mg/24 h组SA、ET-1水平逐渐升高，NO水平逐渐下降，组间比较差异有统计学意义(P<0.05)。Pearson相关分析显示，SA与ET-1水平呈正相关(P<0.05)，与NO水平呈负相关(P<0.05)。 结论 在CKD的进展过程中，SA逐步升高，SA与NO、ET-1相关。

　　【关键词】 糖尿病慢性肾脏疾病;唾液酸;血管内皮功能;一氧化氮;内皮素-1

　　The changes of serum sialic acid in diabetic patients with chronic kidney disease and its relation with vascular endothelial function FAN Xiao-lin，SU Ru-ting，HAN Xiao-jun. Department of Kidney and Endocrinology，The Affiliated Haian Hospital of Nantong University，Hai’an 226600，China

　　Corresponding author：HAN Xiao-jun，E-mail：hanxiaojun008@163.com

　　【Abstract】 Objective To observe the changes of serum sialic acid(SA)and in diabetic patients with chronic kidney disease(CKD) and its relation with vascular endothelial function. Methods 97 T2DM patients were divided into <30 mg/24 h group(n=31)，30～299 mg/24 h group(n=34)and ≥300 mg/24 h group(n=32) according to the level of UAlb/Cr，meanwhile 30 healthy subjects were selected as normal control(NC) group. The level of serum SA，nitric oxide (NO)，endothelin-1(ET-1) in four groups were detected. Results Compared with the NC group，the level of SA and ET-1 were increased gradually in <30 mg/24 h，30～299 mg/24 h and ≥300 mg/24 h group，and the NO were decreased gradually(P<0.05). Pearson correlation analysis showed that the SA level was positively related with ET-1 and negatively with NO(P<0.05). Conclusion The level of SA is increased gradually in the development of CKD，and the SA level is correlated with NO and ET-1.

　　【Key words】 Chronic kidney disease(CKD) in diabetes;Sialic acid(SA);Vascular endothelial function(VEC);Nitric oxide(NO);Endothelin-1(ET-1)