·糖尿病性肾脏疾病·

　　【摘要】 目的 探讨血浆胱抑素C (Cys-C)、同型半胱氨酸(Hcy)与GDM早期肾损害的关系。 方法 选取GDM 患者(GDM)73例、妊娠期IGT者(GIGT)89例、正常妊娠者80名及健康育龄妇女(NGT)80名，比较各组Hcy、Cys-C、Scr、BUN、尿微量白蛋白(MAU)水平。 结果 GDM组Cys-C[(2.94±0.51)vs(1.72±0.37)、(1.14±0.46) mg/L]、Hcy[(22.33±5.32)vs(18.19±4.25)、(13.24±3.16)μmol/L]和MAU [(24.37±5.67)vs(21.72±3.42)、(21.55±4.28) mg/24 h]水平均高于GIGT、正常妊娠组(P<0.05);相关分析显示，Hcy、Cys-C与MAU呈正相关。 结论 Cys-C和Hcy联合检测对GDM早期慢性肾脏疾病诊断可能具有临床意义。

　　【关键词】 糖尿病，妊娠;同型半胱氨酸;胱抑素C;肾损害;尿微量白蛋白

　　Diagnostic values of combination assay of serum cystatin C and homocysteine for early renal injury in patients with gestational diabetes mellitus WANG Jing，YUAN Su-hua，LI Xiao-mei，et al.〖MZ)〗Zhaoqing Medical College，Zhaoqing 526020，China

　　Corresponding author：YUAN Su-hua，E-mail：378145715@qq.com

　　【Abstract】 Objective To explore diagnostic values of combination assay of serum cystatin C(Cyc-C) and homocysteine for early renal injury in patients with gestational diabetes mellitus(GDM). Methods 73 cases with GDM，89 cases with gestational impaired glucose tolerance(GIGT group)，80 cases of normal pregnant women and 80 healthy child bearing women (NGT group) were recruited. The clinical data were compared-among groups. The correlations of serum Hcy and Cys-C with Scr，BUN and MAU were respectively analyzed. Results The patients with GDM versus normal pregnant women and NGT women had higher levels of Cys-C[(2.94±0.51)vs(1.72±0.37)，(1.14±0.46)mg/L]，of Hcy[(22.33±5.32)vs(18.19±4.25)，(13.24±3.16)μmol/L] and of MAU[(24.37±5.67)vs(21.72±3.42)，(21.55±4.28)mg/24 h](P<0.05).The levels of Hcy，Cys-C and MAU were positively correlated in GIGT group. Conclusion Co-detection of serum Cys-C and Hcy may be used as diagnostic indicators for early renal injury in GDM patients.

　　【Key words】 Diabetes，gestational;Homocysteic acid(Hcy);Cystatin C(Cyc-C);Renal injures;Microalbuminuira(MAU)