·糖尿病临床研究·

　　【摘要】 目的 探讨天芪降糖胶囊联合二甲双胍对T2DM患者IL-6、TNF-α和C-RP水平的影响。 方法 80例T2DM患者随机分为对照组和治疗组，各40例。对照组予二甲双胍单药治疗;治疗组在二甲双胍治疗的基础上加用天芪降糖胶囊治疗8周。分别观察治疗前后IL-6、TNF-α、C-RP水平的变化。 结果 与同组治疗前及对照组治疗后相比，治疗组IL-6、TNF-α、C-RP水平降低[(6.79±0.60)，(7.15±0.62) vs (5.08±0.43)pg/ml;(8.94±0.55)，(8.61±0.66) vs (5.18±0.45) pg/ml;(6.79±0.60)，(6.58±0.59) vs (3.56±0.30) mg/L，P<0.01]。 结论 天芪降糖胶囊联合二甲双胍可降低T2DM患者的IL-6、TNF-α及C-RP水平。

　　【关键词】 天芪降糖胶囊;二甲双胍;肿瘤坏死因子α;白介素6;C反应蛋白

　　The effects of Tianqijiangtang capsule combined with Metformin on the levels of interleukin-6，tumor necrosis factorα and C-reactive protein in patients with type 2 diabetes mellitus CAO Yong，WANG Hong-yu，XU Chun. Graduate School of Xuzhou Medical College，Xuzhou 221004，China

　　Corresponding author：XU Chun，E-mail：wjxuchun@sohu.com

　　【Abstract】 Objective To explore the effects of Tianqijiangtang capsule combined with Metformin on the levels of IL-6，TNF-α and C-RP protein in patients with T2DM. Methods 80 T2DM were randomized into control group (treatment with Metformin，n=40) and treatment group (treatment with Tianqijiangtang in combination with Metformin，n=40). The changes of levels of IL-6，TNF-α and C-RP were observed before and after the treatment. Results Compared to the pretreatment in the same group and after treatment in control group，IL-6，TNF-α and C-RP of treatment group were reduced significantly[(6.79±0.60)，(7.15±0.62) vs (5.08±0.43)pg/ml;(8.94±0.55)，(8.61±0.66) vs (5.18±0.45) pg/ml;(6.79±0.60)，(6.58±0.59) vs (5.56±0.30) mg/L，P<0.01]. Conclusion Tianqijiangtang capsule combined with Metformin can decrease the levels of IL-6，TNF-α and C-RP in T2DM patients.

　　【Key words】 Tianqijiangtang capsule;Metformin;Interleukin-6(IL-6);Tumor Necrosis Factor-α(TNF-α);C-reactive protein(C-RP