【摘要】 目的 探讨不同BMI的T2DM患者血清β-抑制蛋白2水平变化及与代谢指标的相关性。 方法 170例T2DM患者分为体重正常(Con)组55例、超重(Ow)组57例及肥胖(Ob)组58例，测定各组相关指标并行统计学分析。 结果 血清β-抑制蛋白2水平在Con、Ow及Ob组分别为(331.31±11.59) vs (321.18±17.47) vs (303.95±13.63) ng/L，组间两两比较，差异有统计学意义(P<0.05)。相关分析 结果 显示，β-抑制蛋白2水平与BMI、TG、FIns、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)呈负相关(r分别为-0.404、-0.328、-0.353、-0.308、-0.260，P<0.01);多元逐步回归分析显示，BMI与β-抑制蛋白2水平独立相关，但未发现β-抑制蛋白2与TG、FIns、HOMA-IR及HOMA-β的相关性。 结论 T2DM患者中，BMI是影响血清β-抑制蛋白2水平降低的独立危险因素。

　　【关键词】 β-抑制蛋白2;糖尿病，2型;体重指数

　　Relationship between serum β-arrestin 2 and metabolic indices in patients with type 2 diabetes mellitus YANG Hua，YANG Xiao-dong，RAO Li-hua，et al.Department of Clinical Laboratory，Renhe Hospital of Three Gorges University，Yichang 443001，China

　　【Abstract】 Objective To investigate the levels of serum β-arrestin 2 in type 2 diabetic (T2DM) patients with different body mass index (BMI) and to analyze the association of serum β-arrestin 2 with metabolic indices. Methods A total of 170 T2DM patients were enrolled and divided into three groups according to BMI as normal weight group (Con，n=55)，over-weight group (Ow，n=57) and obese group (Ob，n=58). Several related indices including blood chemistry values were determined and analyzed statistically. Results (1) Serum β-arrestin 2 levels in Con group，Ow group and Ob group were (331.31±11.59)，(321.18±17.47) and (303.95±13.63) ng/L respectively and the differences of pairwise comparison among three groups were statistically significant (P<0.05). (2) Serum β-arrestin 2 levels were negatively correlated with BMI，TG，FIns，HOMA-IR and HOMA-β (r=-0.404,-0.328,-0.353,-0.308,-0.260，P<0.01). Multiple stepwise regression analysis showed that BMI was independently associated with serum β-arrestin 2. TG，FIns，HOMA-IR and HOMA-β had no association with the levels of serum β-arrestin 2. Conclusion BMI is an independent risk factor for decreased levels of serum β-arrestin 2 in T2DM patients.

　　【Key words】 β-arrestin 2;Diabetes mellitus，type 2;Body mass index(BMI)