·胰岛素抵抗及其相关疾病·

　　【摘要】 目的 观察胰岛β细胞分泌功能与胰岛素抵抗指数(HOMA-IR)在T2DM中的变化。 方法 T2DM患者268例，行75 g OGTT或100 g馒头餐试验，以及C-P释放试验，比较组间各项相关指标的差异。 结果 与病程<5年组比较，病程>10年组胰岛β细胞功能(HOMA-β)下降(P<0.05)。病程>10年组随FPG增加，HOMA-β下降(P<0.01)，HOMA-IR增加，但差异无统计学意义(P>0.05)。 结论 长期良好的控制血糖，可延缓胰岛β细胞功能的衰竭。病程对HOMA-β的损伤低于高血糖。

　　【关键词】 胰岛β细胞功能;胰岛素抵抗;糖尿病，2型;口服葡萄糖耐量试验

　　Research on β cell function and insulin resistance in patients with type 2 diabetes mellitus SUN Jian，DU Qun，WANG Guo-ping，et al.Department of Endocrinology，The Second Affiliated Hospital of Baotou Medical University，Baotou 014030，China

　　Corresponding author：WANG Guo-ping，E-mail：sunjhero78@163.com

　　【Abstract】 Objective To evaluate β cell function，insulin resistance and their changes in patients with type 2 diabetes mellitus (T2DM). Methods A total of 268 T2DM patients were enrolled in this study. 75 g OGTT or 100 g steamed bread meal test and C-peptide release test were measured in all the subjects. Results The β cell function index (HOMA-β) decreased significantly during the progress of T2DM (P<0.05). In T2DM duration>10 years group，the decrease of HOMA-β and the increase in HOMA-IR associated with the increase of FPG did not reach the significant difference (P>0.05). Together with the raising of FPG level，HOMA-β decreased，and the HOMA-IR increased significantly (P<0.01). Conclusion Long-term，well-controlled blood glucose could delay the exhaustion of β cell function. Injury to β cell function based on duration of diabetes is less severe than that of hyperglycemia.

　　【Key words】 Islet β cell function;Insulin resistance(IR);Diabetes mellitus，type 2;Oral glucose tolerance test (OGTT)