·糖尿病神经病变·

　　【摘要】 目的 探讨中老年T2DM患者血尿酸(SUA)水平和DPN的关系。 方法 选取中老年T2DM患者207例，分为单纯T2DM组和DPN组，DPN组根据多伦多评分再分为轻、中、重亚组。对各指标行Pearson相关性分析，并对DPN的危险因素行二分类Logistic回归分析。 结果 DPN组SBP、尿白蛋白/肌酐(UACR)、BUN、血肌酐(Scr)、TC、LDL-C、血尿酸(SUA)水平高于单纯T2DM组，SUA水平随着神经病变严重程度的增加而增加[(279.66±56.53) vs (308.93±52.96) vs (330.24±48.79) μmol/L](P<0.05)。Logistic回归分析结果显示，SUA是DPN的危险因素。 结论 中老年T2DM患者中，SUA是DPN的危险因素，其水平与DPN病情严重程度呈正相关。

　　【关键词】 糖尿病，2型;血尿酸;糖尿病周围神经病变;危险因素

　　Association between serum uric acid level and diabetic peripheral neuropathy in middle-aged and elderly population WANG Guo-feng，XU Ning，YANG Tao.Department of Endocrinology，The First People’s Hospital of Lianyungang，Lianyungang 222000，China

　　Corresponding author：YANG Tao，E-mail：yangt@njmu.edu.cn

　　【Abstract】 Objective To investigate the association between serum uric acid (SUA) level and diabetic peripheral neuropathy(DPN) in middle-aged and elderly population. Methods A total of 207 middle-aged and elderly patients with T2DM were enrolled in this study. All the subjects were divided into two groups：T2DM only group and DPN group. The DPN group was further divided into three subgroups (mild，moderate and severe group) according to TCSS score. Pearson correlation analysis was used to evaluate each index，and binary logistic regression was used for statistical analysis of risk factors for DPN. Results SBP，UACR，BUN，Scr，TC，LDL-C and SUA were significantly higher in DPN group than in T2DM group. SUA were significantly increased together with the increase of the severity of DPN[(279.66±56.53)vs(308.93±52.96)vs(330.24±48.79) μmol/L](P<0.05). Conclusion SUA level is an risk factor for the development of DPN in the middle-aged and elders with T2DM. SUA is positively correlated with the severity of DPN.

　　【Key words】 Diabetes mellitus，type 2;Serum uric acid(SUA);Diabetic peripheral neuropathy(DPN);Risk factors