·糖尿病临床研究·

　　【摘要】 目的 探讨T2DM合并高尿酸血症(HUA)与心血管疾病危险因素的关系。方法 回顾性调查T2DM患者3174例，分析336例T2DM合并HUA患者与心血管危险因素的关系。 结果 T2DM患者3174例，其中，男2441例，女733例，年龄24～91岁，平均(60.23±9.77)岁;T2DM合并HUA(HUA组)患者336例，HUA患病率为10.6%。HUA组年龄≥60岁(65.2% vs 48.1%)、女性(29.3% vs 22.3%)、BMI≥25.0 kg/m2(74.4% vs 59.9%)、TG≥1.70 mmol/L(59.8% vs 42.4%)、TC≥5.7 mmol/L(37.8% vs 29.1%)、HDL-C<1.04 mmol/L(13.7% vs 8.8%)、血肌酐(Scr)≥110 μmol/L(30.4% vs 19.0%)、BUN≥7.0 mmol/L(41.1% vs 26.2%)的患者比例高于单纯T2DM组(P<0.05)。二分类非条件Logistic回归分析显示，高龄、女性、BMI≥25.0 kg/m2、高TG血症、高TC血症、低HDL-C血症、Scr≥110 μmol/L、BUN≥7.0 mmol/L是T2DM患者发生HUA的独立危险因素(P<0.05)。 结论 T2DM患者合并HUA与高龄、女性、肥胖、血脂异常及肾功能减退相关。

　　【关键词】 糖尿病，2型;高尿酸血症;心血管疾病;危险因素

　　Association study of cardiovascular risk factors in type 2 diabetic patients with hyperuricemia LIU Ning，YANG Wen-hao，WU Shou-ling，et al.Department of Oncology，Kailuan Hospital，Tangshan 063000，China

　　Corresponding author：CUI Liu-fu，E-mail：cuiliufu@hotmail.com

　　【Abstract】 Objective To explore the relationship of hyperuricemia (HUA) and cardiovascular risk factors in T2DM. Methods A total of 3174 subjects with T2DM were screened. The relationship between HUA and cardiovascular risk factors were evaluated in 336 subjects with HUA. Results A total of 3174 T2DM were enrolled in this study. Male and female were 2441 and 733 respectively. The average age was (60.23±9.77) years，from 24 to 91 years old. There were 336 patients with HUA. The prevalence rate of HUA was 10.6% in this cohort. The rate of age≥60 years (65.2% vs 48.1%)，female (29.3% vs 22.3%)，BMI≥25.0 kg/m2 (74.4% vs 59.9%)，TG≥1.70 mmol/L (59.8% vs 42.4%)，TC≥5.7 mmol/L (37.8% vs 29.1%)，HDL-C<1.04 mmol/L (13.7% vs 8.8%)，Scr≥110 μmol/L (30.4% vs 19.0%)，BUN≥7.0 mmol/L (41.1% vs 26.2%) in HUA patients were higher than in non-HUA patients (P<0.05). Binary non-conditional logistic regression analysis showed that，advanced age，female，BMI≥25.0 kg/m2，high TG，high TC，low HDL-C，Scr≥110 μmol/L，BUN≥7.0 mmol/L were independent risk factors for HUA in T2DM patients (P<0.05). Conclusion Advanced age，female，obesity，dyslipidemia and renal impairment are associated with the occurrence of HUA in T2DM.

　　【Key words】 Diabetes mellitus，type 2;Hyperuricemia(HUA);Cardiovascular;Risk factors