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男性糖尿病患者睾酮水平变化与氧化应激的关系

来自:中国糖尿病杂志  编辑:岳建美 伊继峰 井庆平 岳翠平|点击数:|2015-07-24

  ·糖尿病临床研究·

  【摘要】 目的 观察影响男性糖尿病患者血清总睾酮(TT)水平改变的因素及其水平改变与氧化应激(OS)的关系。 方法 选取男性T2DM患者108例,测定血清TT水平进行三分位法分组,按数值从低到高分为Tertile1(6.07~12.0 nmol/L)组,Tertile2(12.20~15.37 nmol/L)组及Tertile3(17.14~21.36 nmol/L)组,各36例。检测各组FPG、血脂、HbA1c、胰岛素、血清丙二醛(MDA)和超氧化物歧化酶(SOD)。 结果 与Tertile1组比较,Tertile2组和Tertile3组年龄、BMI、DBP、HbA1c、TG均降低,而Tertile2组SOD升高,Tertile3组MDA降低,SOD升高(P<0.05)。Pearson相关分析显示,TT与HOMA-IR呈负相关(r=-0.576,P<0.01)。多元逐步回归分析显示,TT与TG呈独立负相关(β=-0.937,P<0.01)。 结论 高水平TT组年龄、BMI、DBP、TG、HbA1c及MDA降低,SOD升高。TT与HOMA-IR呈负相关,TT与TG呈独立负相关。

  【关键词】 糖尿病,2型;睾酮;氧化应激

  The relationship between the levels of serum testosterone and oxidative stress in male patients with type 2 diabetes mellitus YUE Jian-mei,YI Ji-feng,JING Qing-ping,et al.Department of Endocrinology,The First Hospital of Zibo City,Zibo 255200,China

  Corresponding author:JING Qing-ping,E-mail:jingqingping@medmail.com.cn

  【Abstract】 Objective To observe the influencing factors of serum total testosterone(TT) and relationship between the serum TT and oxidative stress in male patients with T2DM. Methods 108 male patients with T2DM were enrolled. FPG,blood lipid,HbA1c,insulin,serum TT,serum malondialdehyde(MDA) and superoxide dismutase (SOD) were detected. According the TT level,subjects were divided intotertiles(the lowest tertile-tertile1,the middle tertile-tertile2 and the highest tertile-tertie3). Results Compared with tertile1,the levels of age,BMI,DBP,HbA1c,TG,MDA and SOD were significantly different for tertile3(P<0.05) and the levels of age,BMI,DBP,HbA1c,TG and SOD were significantly different for tertile2(P<0.05). TT had negative correlation with HOMA-IR(r=-0.576,P<0.01). TT had independent negative correlation with TG(β=-0.937,P<0.01). Conclusion BMI,DBP,HbA1c and TG are risk factors for TT reduction. TT is negatively correlated with HOMA-IR. Enhanced oxidative stress levels may play an important role in the pathogenesis of TT reduction in male patients with T2DM.

  【Key words】 Diabetes mellitus,type 2; Testosterone; Oxidative stress(OS)

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