【摘要】 目的 探讨T2DM合并高尿酸血症(HUA)患者与FC-P和IR的相关性。 方法 纳入T2DM患者353例，按血清尿酸(SUA)水平分为T2DM合并HUA(T2DM+HUA)组57例和单纯糖尿病(T2DM)组296例。根据FC-P水平采用四分位数法分为C1(<1.5 ng/ml)、C2(1.5～1.8 ng/ml)、C3(1.8～2.7 ng/ml)和C4(≥2.7 ng/ml)亚组。 结果 两组BMI、TG、HDL-C、LDL-C、胰岛素抵抗指数(HOMA-IR)、ISI、FC-P、Scr、肾小球滤过率(eGFR)、动脉硬化指数(ASI)比较，差异均有统计学意义(P均<0.05)。相关分析结果显示，SUA与血脂、肾功能、HOMA-IR和FC-P有相关性(P均<0.05)。各亚组SUA水平和HUA发病率随FC-P水平逐渐升高，差异均有统计学意义(P均<0.05)。与C1～C3亚组相比，C4亚组发生T2DM合并HUA的风险增加(P=0.026)，校正相关因素后，OR减少，差异无统计学意义(P=0.057)。 结论 T2DM患者合并HUA与FC-P、IR及血脂异常相关，FC-P高可能是T2DM患者发生HUA的危险因素。

　　【关键词】 糖尿病，2型;高尿酸血症;胰岛素抵抗

　　【Abstract】 Objective To investigate the relationship of hyperuricemia with fasting C peptide(FC-P) and insulin resistance(IR) in T2DM patients. Methods The 353 T2DM patients were divided into with high uric acid (T2DM+HUA) group and without high uric acid (T2DM) group according the level of serum uric acid(SUA). Meanwhile, All subjects were divided into four subgroups: C1(<1.5 ng/ml)， C2(1.5～1.8 ng/ml)，C3(1.8～2.7 ng/ml) and C4 subgroup(≥2.7 ng/ml)according to FC-P. Results There were statistically significant differences in BMI, TG, HDL-C, LDL-C, HOMA-IR, ISI, FC-P, Cr, eGFR, and ASI between two groups (P<0.05). Correlation analysis result showed that the SUA was correlated with lipids, renal function, HOMA-IR and FC-P(P<0.05). The level of SUA and HUA incidence was increased with FC-P level among subgroups (P<0.05). The risk of T2DM combine hyperuricemia was higher in C4 subgroup than in other groups(P=0.026). After adjusting the related risk factors, the OR was reduced, and there was no statistically significant differences(P=0.057). Conclusion Hyperuricemia was correlated with FC-P, IR and dyslipidemia in T2DM patient. The high FC-P level maybe the risk factors for hyperuricemia in T2DM patients.

　　【Key words】 Diabetes mellitus, type 2; Hyperuricemia; Insulin resistance(IR)