【提要】  T2DM患者常伴有高血糖、脂代谢异常、高血压、肥胖及IR等危险因素，从而导致血管内皮细胞功能障碍，增加心血管事件风险。GLP-1类似物及其受体激动剂，作为一种基于肠促胰素的治疗糖尿病新方法，其除了有效控制血糖外，对血管内皮细胞功能障碍也有改善作用。本研究概述了GLP-1类似物及其受体激动剂对血管内皮细胞的保护作用。

【关键词】  胰升糖素样肽-1；血管内皮细胞；糖尿病，2型

Research progress of protective effect of GLP-1 receptor agonist on vascular endothelial cell

      【Summary】  Type 2 diabetic patients often have risk factors such as hyperglycaemia, dyslipidaemia, hypertension, obesity and insulin resistance, which increase the risks of vascular endothelial dysfunction and cardiovascular events. GLP-1 analogue and its receptor agonist, is a novel therapy on diabetes targeting at incretin, which can effectively control blood glucose and improve vascular endothelial dysfunction. Here we summarize the protective effect of GLP-1 analogue and its receptor agonist on vascular endothelial cell.  

      【Key words】  Glucagon-like peptide-1(GLP-1); Vascular endothelial cell; Diabetesmellitus, type 2