【关键词】  胆汁酸；成纤维细胞生长因子19；胰升血糖素样肽-1；肝脏；葡萄糖代谢

Bile acid induced gut hormones and hepatic glucose metabolism  

【Summary】  Bile acid is a main component of bile, which plays a key role in keeping cholesterol metabolism balance in vivo and promoting lipids digestion in intestine. Recently, more and more researches focus on bile acid for its regulating effect on glucose, lipid and energy metabolism as a signal molecule. The reabsorbed bile acid stimulates the secretion of fibroblast growth factor 19(FGF19) and glucagon-like peptide-1(GLP-1) in the intestine by activating a nuclear receptor farnesoid X-activated receptor (FXR) and a membrane receptor TGR5. FGF19 and GLP-1 regulate hepatic glucose metabolism through different pathways. Here, we briefly summarize the research progress and relationship between bile acid induced gut hormones and hepatic glucose metabolism.

【Key words】  Bile acid；Fibroblast growth factor19 ；Glucagon-like peptides-1；Liver；Glucose metabolism