·糖尿病临床研究·

　　【摘要】 目的 探讨2型糖尿病T2DM微血管病变与血清血小板反应蛋白-1(TSP-1)的相关性。 方法 将176例受试者研究对象分为糖尿病合并有微血管病变组组(A组，n=58例)、无、未合并微血管病变组(B组，n=64例)和与正常对照组(C组，，n=54例)，检测所有研究对象血清TSP-1水平及相关临床指标，并计算胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)。 结果 A组及、B组的血清TSP-1水平均显著高于C组(P<0.05)，A组的血清TSP-1水平显著高于B组(P<0.05)。相关分析示，血清TSP-1水平与FBG、HbA1Cc、hs-C-RP呈正相关(P<0.01)，与HOMA-β指数及FINSns呈负相关(P<0.01)。多元线性逐步回归结果显示：，HbA1Cc、FPG、HOMA-β及FINSns是血清TSP-1水平的独立影响因素(P<0.05)。 结论 TSP-1在2型糖尿病T2DM微血管病变患者血清中表达升高，其可能参与糖尿病微血管病变病理生理过程，检测血清TSP-1的水平对预测糖尿病微血管病变有一定的价值。

　　【关键词】 血清血小板反应蛋白-1TSP-1;2型糖尿病,2型;微血管病变。

　　【Abstract】 Objective To explore the relationship of serum thrombospondin -1 (TSP-1) in T2DM patients with microangiopathy complications in T2DM patients . Methods A total of 176 cases were divided into 3 groups: T2DM patients with microangiopathy complications group (group A, 58 cases) , T2DM patientsand without microangiopathy complications group (group B, 64 cases) microangiopathy complications and normal controls group(group C, 54 cases).The serum TSP-1 and other clinical indicators of all the cases were detected .Use The steady -state model was used to account for the indexes of insulin resistance (HOMA- IR) and islet beta cell function index (HOMA-β). Results The serum TSP-1 levels in type 2 diabetes with and without microangiopathy complications were significantly higher in group A and B than those in control group C(P<0.05). Furthermore, among type 2 diabetes,serum TSP-1 level was higher in patients with microangiopathygroup A than those withoutin group B(P<0.05). AThe multivariate correlation analysis showed that serum TSP-1 level positively correlates with FBGG, 、HbA1c、hs-C-RP(P<0.01)，while negatively with HOMA-βand FINSns(P<0.01). Stepwise linear multiple regression revealed that HbA1Cc、FBG、HOMA-βand FINSns (P<0.05)were the independent factors of serum TSP-1 level(P<0.05). Conclusion The serum TSP-1 levels is elevated in T2DM patients with microangiopathy，suggesting that it might play a role in the pathophysiology of diabetic microangiopathy，.The serum TSP-1 has and it is significant value in predicting the microangiopathy of theseT2DM patients.

　　【Key words】 ThrombospondinThrombospondin 1-1;Type 2 dDiabetes mellitus, type 2;; Microangiopathy, diabetic