·糖尿病临床研究·

　　何泉 罗海明 唐新华 朱宝生 陈安宝 陈嘉勇

　　作者单位：650032昆明，云南省第一人民医院急诊科(何泉、罗海明、唐新华、朱宝生);昆明医学院附属第二医院(陈安宝、陈嘉勇)

　　【摘要】目的探讨血糖控制对高血糖危象患者外周血单核细胞趋化蛋白-1(MCP-1)水平的影响。方法选取DKA和非酮症高血糖高渗(NKH)患者84例检测其治疗前后外周血单核细胞趋化蛋白MCP-1水平变化，以56名健康体检者作对照。结果在血糖控制达标后，高血糖危象组治疗前MCP-1水平显著高于健康对照组(P<0.05);高血糖危象组治疗前后外周血单核细胞趋化蛋白MCP-1水平差异有显著的统计学意义(P<0.05)。相关分析显示外周血单核细胞趋化蛋白MCP-1水平与FBG、2hBG、HOMA-IR呈正相关(r=0.506，r=0.854，r=0.283，P<0.01)。结论血糖控制后外周血单核细胞趋化蛋白MCP-1水平明显下降，血糖下降带来炎症状态的改变。

　　【关键词】高血糖危象;炎症;MCP-1;糖尿病，2型

　　doi:10.3969/j.issn.1006-6187.2012.03.017

　　The effects of blood glucose control on levels of monocyte chemoattractant protein-1(MCP-1)activity in peripheral blood of patients with hyperglycemic crisisHE Quan, LUO Hai-ming, TANG Xin-hua, et al. Department of Emergency, First People’s Hospital of Yunnan Province, Kunming 650101, P. R. China

　　【Abstract】ObjectiveTo investigate the effects of blood glucose control on levels of monocyte chemoattractant protein-1(MCP-1)activity in peripheral blood of patients with hyperglycemic crisis.MethodsA total of 84 patients with diabetic ketoacidosis(DKA)and nonketotic hyperglycemia(NKH) patients were selected. MCP-1 levels were assayed at 72 hours after glucose control. Serum MCP-1 was assayed by ELISA.ResultsThe serum MCP-1 before treatment were higher in patients with hyperglycemia crisis than in normal control. The relationship analysis showed that MCP-1 levels were positivily related to fasting blood glucose (FBG), 2-h postprandial glucose,and HOMA-IR(r=0.506，r=0.854，r=0.283，P<0.01).ConclusionThe levels of serum MCP-1 are decreased at 72 hours after blood glucose control. The improvement of blood glucose control contributes to the improvement of inflammatory status.

　　【Key words】Hyperglycemia crisis; Inflammation;Monocyte chemoattractant protein-1(MCP-1); Diabetes mellitus，type 2