·糖尿病临床研究·

　　窦攀 王学美 富宏 房颖 刘庚信 张前进 褚松龄

　　基金项目：国家重点基础研究发展计划(973计划)项目(2009CB523003)

　　作者单位：100034北京大学第一医院中西医结合研究室

　　通信作者：王学美， E-mail：wangxuemeibjmu@163.com

　　【摘要】目的探讨IGR患者氧化应激和炎症标志物的水平及其与胰岛功能、糖脂代谢指标的相关性。方法选取门诊IGR患者、DM患者和正常人(NGT)进行相关数据统计分析。结果NGT组、IGR组和DM组SOD依次降低，MDA、C-RP、IL-6、TNF-α依次升高。SOD与HOMA-IR呈中度负相关，与HOMA-β、△I30/△G30、△I120/△G120呈中度正相关; MDA与C-RP、IL-6、TNF-α与HOMA-IR呈中度正相关，与HOMA-β、△I30/△G30、△I120/△G120呈中度负相关。影响SOD、MDA、C-RP、IL-6、TNF-α的主要因素有WHR、HbA1c、TG。结论在IGR阶段，机体已经受到明显的氧化应激损伤，并发生炎症反应的激活。

　　【关键词】糖调节受损;氧化应激;炎症

　　doi:10.3969/j.issn.1006-6187.2012.03.014

　　Clinical analysis of oxidative stress damage and inflammatory markers in patients with impaired glucose regulationDOU Pan, WANG Xue-mei, FU Hong, et al. Department of Integrated Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China

　　Corresponding author: WANG Xue-mei, E-mail: wangxuemeibjmu@163.com

　　【Abstract】ObjectiveTo investigate the level of oxidative stress damage and inflammatory markers in patients with IGR, and to analyze the correlation of the markers with islet function, glucose and lipid metabolism.MethodsOutpatient cases were selected from Traditional Chinese Medicine Department of Peking University First Hospital, who had received a blood test of glucose, lipid and insulin. The 80 cases meeting the diagnostic criteria of IGR and the 48 cases meeting the diagnostic criteria of type 2 diabetes mellitus were the study subjects, and the other 40 people with normal glucose tolerance were the healthy control group. Related data of three groups were analyzed.ResultsIn NGT group, IGR group and T2DM group, antioxidants SOD decreased when oxidative stress end products MDA and inflammatory markers C-RP, IL-6 and TNF-α increased. SOD had a moderately negative correlation with HOMA-IR, and had a moderately positive correlation with HOMA-β, △ I30 / △ G30 and △ I120 / △ G120. MDA, C-RP, IL-6 and TNF-α showed a moderately positive correlation with HOMA-IR, and a moderately negative correlation with HOMA-β, △ I30 / △ G30 and △ I120 / △ G120. WHR, HbA1c and TG were main influencing factors of SOD, MDA, C-RP, IL-6 and TNF-α.ConclusionIn IGR stage, patients have been subjected to oxidative stress injury which activates the inflammatory response. Oxidative stress and inflammation form a vicious cycle, which to a certain extent increases insulin resistance and impairs the function of pancreatic islet β cells. Abdominal obesity, long-term high blood glucose and hyperlipidemia are the main factors of oxidative stress and inflammation.

　　【Key words】Impaired glucose regulation; Oxidative stress; Inflammation