·糖尿病性肾脏疾病·

　　周新人 刘永铭 杨琳 王晓玉 陈敏娟

　　作者单位：730000兰州，兰州大学第一医院老年病科(第一作者现在兰州军区总医院安宁分院感染科工作)

　　通讯作者：刘永铭，E-mail:cardtonm@263.net

　　【摘要】 目的 探讨2型糖尿病患者血、尿补体活化片段C5a含量的变化与糖尿病肾病的关系。 方法 选2型糖尿病患者39例，健康体检者21名作为对照，检测血、尿C5a浓度以及血高敏C反应蛋白，测定尿白蛋白排泄率以及血糖控制情况，分析其关系。 结果 与对照组比较，2型糖尿病患者尿C5a浓度升高(11.4±21.1 vs 76.3±144.4，P<0.05)，血C5a无明显变化, 尿C5a与尿白蛋白排泄率正相关(γ=0.378，P<0.05)，糖尿病病程、尿C5a是尿白蛋白排泄率的独立预测因素。 结论 补体活化可能与糖尿病肾病的发生有关。

　　【关键词】糖尿病，2型;尿白蛋白排泄率;C5a

　　doi:10.3969/j.issn.1006-6187.2011.04.008

　　The relationship between complement C5a and UAER in type 2 diabetes mellitus

　　ZHOU Xin-ren, LIU Yong-ming, YANG Ling, et al. Department of Gerontology，the First Hospital of Lanzhou University，Lanzhou 730000， China

　　Correspording author: LIU Yong-ming, E-mail: cardtonm@263.com

　　【Abstract】 Objective To investigate the relationship between complement C5a and diabetic nephropathy. Methods The concentration of plasma C5a and urine C5a was examined in 39 patients with type 2 diabetes mellitus, 21 healthy volunteers as controls . The relationship between complement C5a and UAER was analyzed. Results Urinary level of C5a was higher in the diabetic nephropathy group than in control (76.3±144.4 vs 11.4±21.1，P=0.046), Urinary C5a was positively correlated with UAER. The diabetic course and urinary C5a were the independent predictors of urine albumin excretion rate (UAER)(γ=0.378，P=0.023). Conclusion The activation of complements might involve in the pathogenesis of diabetic nephropathy.

　　【Key words】Diabetes mellitus, type 2; Urine albumin excretion rate; C5a