·胰岛素抵抗及其相关疾病·

　　刘乐桐 刘扬 宫英丽 何冰 张咏言 韩萍

　　作者单位：110004沈阳，中国医科大学附属盛京医院内分泌科(刘乐桐、刘扬、何冰、张咏言、韩萍)，体检中心(宫英丽)

　　通讯作者：韩萍，E-mail: hanping85@hotmail.com

　　基金项目：辽宁省教育厅科学技术基金项目(20060999)

　　【摘要】 目的 观察向心性肥胖患者的8-异前列腺素(8-iso-PGF2α)水平及其与胰岛素抵抗的关系。 方法 筛选糖耐量正常的向心性肥胖患者(包括胰岛素抵抗与无胰岛素抵抗者)及正常对照组。分别测定血清8-iso-PGF2α，丙二醛(MDA)，游离脂肪酸(FFA)等。 结果 向心性肥胖组8-iso-PGF2α、MDA、胰岛素抵抗指数(HOMA-IR)、FFA均显著高于对照组(P<0.05)。8-iso-PGF2α差异最显著(P<0.01)，且与FFA、BMI及甘油三酯(TG)呈显著正相关。胰岛素抵抗亚组的8-iso-PGF2α水平显著高于无胰岛素抵抗亚组。多元回归分析显示，8-iso-PGF2α与HOMA-IR相关性最强。 结论 糖耐量正常的向心性肥胖患者氧化应激增强，且氧化应激是胰岛素抵抗的重要危险因素，循环中8-iso-PGF2α水平能更好地反映其程度。

　　【关键词】向心性肥胖;8-异前列腺素;氧化应激;胰岛素抵抗

　　doi:10.3969/j.issn.1006-6187.2011.04.002

　　The level of 8-iso-prostaglandin F2α(8-iso-PGF2α)in the central obese patients with normal glucose tolerance (NGT) and its relationship with insulin resistance

　　LIU Le-tong, LIU Yang, GONG Ying-li, et al. Department of Endocrinology, Shengjing Hospital, China Medical University,Shenyang 110004,China

　　Corresponding author: HAN Ping, E-mail: hanping85@hotmail.com

　　【Abstract】 Objective To investigate the level of 8-iso-prostaglandin F2α(8-iso-PGF2α)and its relationship with insulin resistance in central obese patients with NGT. Methods Two hundred and twenty-two subjects were enrolled and divided into two groups: central obese group (n=123) and normal control group(NC, n=99). The central obese group was subdivided into insulin resistance(IR) group and non-IR group. Serum 8-iso-PGF2α, malondialdehyde (MDA), free fatty acids (FFA), IL-6, TNF-α， and lipid were measured. Results Compared with the control group, the levels of 8-iso-PGF2α(P= 0.001), body mass index(BMI), waist circumference(WC), triglyceride (TG), cholesterol (TC), high density lipoprotein(HDL), FFA, MDA and insulin resistance index (HOMA-IR) significantly increased in obese group(all P<0.05), and they increased even more in IR sub-group than those in non-IR sub-group.The level of 8-iso-PGF2α had independently positive correlation with HOMA-IR. Conclusion Oxidative stress increases in central obese patients with NGT,and it plays an important role in insulin resistance. The level of serum 8-iso-PGF2α is a better parameter indicating the extent of oxidative stress.

　　【Key words】Central obesity; 8-iso-prostaglandins F2α; Oxidative stress; Insulin resistance