韦玉和 许联红 罗春媛 冯小芬 周斌 戚传平

　　作者单位：213002常州，江苏大学附属武进医院内分泌科

　　【摘要】目的 探讨2型糖尿病(T2DM)患者外周血基质细胞衍生因子1(SDF-1)水平与大血管并发症的关系。方法 测定55例无微血管并发症的T2DM患者和26名健康对照者外周血中SDF-1水平、内皮祖细胞(EPCs)数量、EPCs表面SDF-1的受体CXCR4表达率。糖尿病患者分单纯糖尿病组、大血管病变组。结果SDF-1水平和EPCs数量对照组、单纯糖尿病组、大血管病变组依次降低(P<0.05或0.01);单纯糖尿病组、对照组、大血管病变组CXCR4表达率依次降低(P<0.05或0.01);SDF-1水平与EPCs数量成正相关(r=0.327,P<0.05)，颈动脉内膜中层厚度与SDF-1、EPCs负相关(r=-0.342、-0.298,P<0.05)。结论 T2DM患者外周血中SDF-1/CXCR4轴的变化与大血管并发症的发生、发展有关。

　　【关键词】基质细胞衍生因子1;CXCR4;内皮祖细胞 ;糖尿病，2型;大血管并发症

　　doi:10.3969/j.issn.1006-6187.2011.01.012

　　Association of serum level of stromal cell-derived factor-1 with macrovascular complications of type 2 diabetes mellitus

　　WEI Yu-he, XU Lian-hong, LUO Chuen-yuan, et al. Department of Endocrinology, Affiliated Wujin Hospital,Jiangsu University,Changzhou,Jiangsu 213002, China

　　【Abstract】Objective　　To study the association of serum level of stromal cell-derived factor-1(SDF-1) and its receptor CXCR4 of endothelial progenitor cells (EPCs)from peripheral blood with macrovascular complication of type 2 diabetes mellitus(T2DM).   Methods  The study subjects included simple diabetics (n=25), macrovascular complication group (n)=30) and healthy control (n=26). The level of serum SDF-1, the positive rate of CXCR4 on EPCs and the number of EPCs were determined.  Results  SDF-1 level and EPCs number were decreased one by one from control group to simple diabetic group and to the macrovascular complications group(P<0.05 or 0.01). CXCR4 expression rate were significantly decreased one by one from the simple diabetic group to the control group and to the macrovascular complications group (P<0.05 or 0.01). SDF-1 level was positively correlated with EPCs number. (r=0.327,P<0.05), carotid intima-media thickness were negatively correlated with SDF-1 and EPCs (r=-0.342,-0.298, P<0.05) in T2DM.  Conclusion  SDF-1/CXCR4 may be related to macrovascular complications in patients with T2DM.

　　【Key words】Stromal cell-derived factor-1; CXCR4; Endothelial progenitor cells; Diabetes mellitus; type 2; Macrovascular complicatins