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糖尿病患者尿液中期因子与糖尿病肾病的关系

来自:中国糖尿病资讯网  编辑:zhaochun|点击数:|2011-10-20

  ·糖尿病性肾脏疾病·

  吴天凤 李红 袁放 江缨 周欢琴 董雪红

  作者单位:310013杭州,浙江大学附属邵逸夫医院内分泌科(吴天凤、李红、董雪红);浙江医院内分泌科(袁放、江缨),检验科(周欢琴)(第一作者现在浙江医院工作)

  通讯作者:吴天凤,E-mail:xllx01@yahoo.com.cn

  【摘要】 目的 探讨尿液中期因子(MK)与糖尿病肾病的关系。 方法 96例糖尿病患者,根据尿白蛋白排泄率分为正常白蛋白尿组(NUAlb组),微量白蛋白尿组(MUAlb组),大量白蛋白尿组(CUAlb组),设对照组(NC组)。用酶联免疫吸附法测定尿液MK水平。 结果 CUAlb组尿液MK水平高于NC组、NUAlb组及MUAlb组(P<0?01),MUAlb组高于NC组及NUAlb组(P<0?05),NUAlb组与NC组差异无统计学意义(P>0?05)。相关分析显示,尿液MK与尿白蛋白排泄率(r=0?40,P<0?05)及病程(r=0?23,P<0?05)呈正相关,与内生肌酐清除率(CCr)呈负相关(r=-0?20,P=<0?05)。 结论 尿液MK可能参与临床糖尿病肾病的发生。

  【关键词】糖尿病肾病;中期因子;蛋白尿

  doi:10.3969/j.issn.1006-6187.2011.01.006

  The relationship between the level of urine midkine and diabetic nephropathy in type 2 diabetes

  WU Tian-feng,LI Hong,YANG Fang,et al.

  Department of Endocrinology. SHAO Yi-Fu Hospital, Zhejiang University School of Medicine,Hangzhou 310013,China

  Corresponding author:WU Tian-feng,E-mail:xllx01@yahoo.com.cn

  Corresponding author:

  【Abstract】 Objective To explore the relation between urine midkine (a heparin-binding growth factor) and diabetic nephropathy in type 2 diabetic patients. Methods Ninety-six patients with type 2 diabetes mellitus were selected and divided into three groups: normal albuminuria group(NUAlb), the microalbuminuria group(MUAlb) and the macroalbuminuria group(CUAlb). The control group consisted of thirty normal subjects(Con). Urine midkine was measured by ELISA. Results Along with the urine albumin excretion rate gradually increased, the urine midkine level was increased (P<0?01). There was a positive correlation of the urine midkine level with urinary albumin excretion rate(r=0?40, P=0?00) and diabetic duration(r=0?23, P=0?04), and a negative correlation between the urine midkine level and serum creatinine clearance rate(r=-0?20, P=0?03). Conclusions Urine midkine may play a role in the pathogenesis and development of diabetic nephropathy.

  【Key words】Diabetic nephropathy; Midkine; Albuminuria

上一篇:尿白蛋白排泄率异常的2型糖尿病患者尿N-乙酰-β-葡萄糖苷酶、α1-微球蛋白及视黄醇结合蛋白检测的改变 下一篇:中性粒细胞明胶酶相关载脂蛋白对糖尿病肾病早期诊断的意义