▪糖尿病临床研究·

　　【摘要】 目的 探讨T2DM患者不同HbA1c水平与尿酸排泄分数(FEUA)的相关性。 方法 选取T2DM患者336例，根据HbA1c水平分为≤7%、7%～9%、≥9%三组，比较各组身高、体重、血压、FPG及2 hPG、FIns及2 hIns、HbA1c、血脂、SUA、肝肾功能指标、生化指标等。 结果 随HbA1c水平的升高，FPG、2 hPG均增高，2 hIns水平下降(P<0.05);eGFR及FEUA升高，SUA水平下降(P均<0.05)。多元线性回归分析结果显示，FEUA与SUA、eGFR呈负相关，与HbA1c呈正相关。 结论 HbA1c水平与FEUA相关，FEUA可能成为预测糖尿病性慢性肾脏疾病指标之一。

　　【关键词】 糖尿病，2型;糖化血红蛋白;尿酸排泄分数

　　【Abstract】 Objective To investigate the relationship between HbA1c and fraction excretion of uric acid (FEUA) in patients with type 2 diabetes mellitus(T2DM). Methods According to the level of HbA1c, 336 T2DM patients were divided into three groups: HbA1c,≤7%、7%～9% and ≥9%. Clinical and biochemical indicators were collected and analyzed. Results Accompanied with the elevation of HbA1c levels, fasting blood glucose and 2 h blood glucose significantly increased, but the levels of 2 h insulin significantly decreased (all P<0.05). Multiple linear regression analysis showed that the levels of FEUA were negatively correlated with uric acid and glomerular filtration rate, but positively correlated with HbA1c. Conclusion HbA1c levels were closely associated with FEUA that may be one of the indicators to predict diabetic nephropathy.

　　【Key words】 Diabetes mullitus, type 2;HbA1c;FEUA