讲座

　　[提要] T1DM是一种常见的自身免疫疾病，但其发病机制尚未完全明确。近年来的研究发现，肠道菌群紊乱可能通过改变肠壁通透性及免疫功能参与了T1DM的进程。使用一些抗生素或益生菌有助于维持肠道菌群的平衡，延缓T1DM的发展，为研究T1DM的发病机制及治疗开阔思路。

　　[关键词] 肠道菌群;糖尿病,1型;肠道屏障

　　【Summary】The pathogenesis of type 1 diabetes(T1DM), which is a common autoimmune disease, has not been understood completely. Increasing evidences have shown that dysbiosis of gut microbiota might involve in the development of T1DM by altering intestinal permeability and immune function. Some antibiotics or probiotics may help to maintain the balance of gut microbiota and delay the development of T1DM. These findings broaden the insight on the pathogenesis and treatment of T1DM.

　　【Key words】 Gut microbiota; Diabetes mellitus, type 1; Gut barrier